Journal article
Functional and structural alterations in the cingulate motor area relate to decreased fronto-striatal coupling in major depressive disorder with psychomotor disturbances
B Liberg, P Klauser, IH Harding, M Adler, C Rahm, J Lundberg, T Masterman, C Wachtler, T Jonsson, M Kristoffersen-Wiberg, C Pantelis, B Wahlund
Frontiers in Psychiatry | FRONTIERS MEDIA SA | Published : 2014
Abstract
Psychomotor disturbances are a classic feature of major depressive disorders. These can manifest as lack of facial expressions and decreased speech production, reduced body posture and mobility, and slowed voluntary movement. The neural correlates of psychomotor disturbances in depression are poorly understood but it has been suggested that outputs from the cingulate motor area (CMA) to striatal motor regions, including the putamen, could be involved. We used functional and structural magnetic resonance imaging to conduct a region-of-interest analysis to test the hypotheses that neural activation patterns related to motor production and gray matter volumes in the CMA would be different betwe..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank Kerstin Eriksson at the MRI Unit, Radiology Clinic, Karolinska University Hospital Huddinge for clinical assistance during scanning. We thank Andrew Zalesky for valuable comments on methodology. We also thank staff members of the Section of Affective Disorders, the Southwest Psychiatric Clinic (PSSV), Stockholm County Council, for assistance with recruiting patients. Benny Liberg received funding from Svenska Lakaresallskapet (The Swedish Society of Medicine, SLS-403101), the Southwest Psychiatric Clinic (PSSV), Stockholm County Council, and the Strategic Research Committee, Karolinska Institutet/Stockholm County Council, Sweden. Paul Klauser was supported by the Swiss National Science Foundation and the Swiss Society for Medicine and Biology Scholarships(ID: 148384). Professor Christos Pantelis was supported by a NHMRC Senior Principal Research Fellowship, Australia (ID: 628386).